Commentary: Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus

نویسندگان

  • Mohamed A. Sabry
  • Mona Fares
  • Ronnie Folkesson
  • Mariam Al-Ramadan
  • Jarrah Alabkal
  • Ghada Al-Kafaji
  • Moustapha Hassan
چکیده

Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain, 2 Experimental Cancer Medicine, Laboratory Medicine, Karolinska Institute, Stockholm, Sweden, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden, 4 Biotechnology Program, College of Postgraduate Studies, Arabian Gulf University, Manama, Bahrain, Department of Molecular Medicine/Al-Jawhara Centre for

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus

Analyses of mice carrying a deletion of the pan-neurotrophin receptor p75NTR have allowed identifying p75NTR as an important structural regulator of the hippocampus. Most of the previous analyses were done using p75NTR (ExIII) knockout mice which still express the short isoform of p75NTR. To scrutinize the role of p75NTR in the hippocampus, we analyzed adult and aged p75NTR (ExIV) knockout mice...

متن کامل

Reduced Anxiety-Like Behavior and Altered Hippocampal Morphology in Female p75NTRexon IV−/− Mice

The presence of the p75 neurotrophin receptor (p75NTR) in adult basal forebrain cholinergic neurons, precursor cells in the subventricular cell layer and the subgranular cell layer of the hippocampus has been linked to alterations in learning as well as anxiety- and depression- related behaviors. In contrast to previous studies performed in a p75NTR(exon III-/-) model still expressing the short...

متن کامل

Repeated administration of cannabinoid receptor agonist and antagonist impairs short and long term plasticity of rat’s dentate gyrus in vivo

Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...

متن کامل

Effect of Clenbuterol Administration into the Basolateral Amygdala on Synaptic Plasticity in Dentate Gyrus Granule Cells in Male Rats

 Background and purpose: Neural circuits and neurotransmitter systems within the basolateral amygdala (BLA) play roles in forming emotional memory through communication with the hippocampus. Therefore, in this study, the role of these neural circuits on synaptic plasticity was investigated by agonist injection of beta-adrenergic receptors into the BLA. Materials and methods: In this experiment...

متن کامل

Beneficial effect of Boswellia serrata gum resin on spatial learning and the dendritic tree of dentate gyrus granule cells in aged rats

Objective: The hippocampal formation, particularly the dentate gyrus (DG), shows age-related morphological changes that could cause memory decline. It is indicated that Boswellia resins attenuates memory deficits and the major component of Boswellia serrata (Bs) gum resin, beta boswellic acid increased neurite outgrowth and branching in hippocampal neurons. This study was designed to investigat...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2016